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晚期创伤性脑损伤中的陶成像:A [18F]MK-6240正子发射断层扫描研究
Greet Vanderlinden1, Laura Michiels2,3,4,5, Michel Koole1
1Nuclear Medicine and Molecular Imaging, Imaging and Pathology, and Departments of Research Group Psychiatry, KU Leuven, Leuven, Belgium.
Journal of neurotrauma
|December 1, 2023
概括
一次创伤性脑损伤 (TBI) 似乎不会在多年后在大脑中引起神经纤维状结 (NFT). 这项研究发现,与对照人群相比,TBI患者的TAU-PET标记物摄取量没有增加.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 神经病理学神经病理学
背景情况:
- 创伤性脑损伤 (TBI) 是阿尔茨海默病 (AD) 的已知危险因素.
- 神经纤维状结 (NFTs) 是AD的标志,在重复性TBI后的慢性创伤性脑病中也发现.
- 目前尚不清楚单一的TBI事件是否会导致NFT积累.
研究的目的:
- 调查在至少两年前经历过一次TBI的个人中存在NFT.
- 评估单个TBI是否足以导致PET成像检测到的NFT积累.
主要方法:
- 在14名TBI患者和40名对照组中进行了一项[18F]MK-6240正子发射断层扫描 (PET) 成像研究.
- 同时进行PET和MRI扫描,以及神经心理评估 (CANTAB,MMSE).
- 应用了Voxelwise部分体积校正和标准化吸收值比率 (SUVR) 的计算.
主要成果:
- 视觉评估显示,TBI患者的标记物吸收没有全球或焦点增加.
- 组级分析显示,TBI患者和对照人群之间的[18F]MK-6240 SUVR没有显著差异.
- 包括执行功能,注意力和全球认知在内的认知功能与TBI组内的[18F]MK-6240 SUVR相关.
结论:
- 在单次TBI后至少两年扫描的患者中,没有检测到[18F]MK-6240脑吸收的基于群体的增加.
- 这表明NFT在单个TBI后的最初几年没有积累.
- 在TBI患者中,TAU PET吸收和认知结果之间的相关性需要进一步调查.
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