下肢骨关节炎会改变运动皮层下降驱动和自愿激活吗? 一个系统的审查和元分析
Myles C Murphy1,2, Christopher Latella3,4, Ebonie K Rio5,6,7
1Nutrition & Health Innovation Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia.
EFORT open reviews
|December 1, 2023
概括
与健康人相比,患有膝关节关节炎的人在四头肌自愿激活 (VA) 中表现出显著的损伤. 部和膝盖OA也导致更痛苦的四肢中更大的VA赤字.
科学领域:
- 神经科学是一个神经科学.
- 整形外科 整形外科 整形外科
- 康复科学 康复科学 康复科学
背景情况:
- 骨关节炎 (OA) 是一种普遍存在的退行性关节疾病.
- 下肢骨关节炎显著影响移动性和生活质量.
- 了解OA中运动控制缺陷对于有效管理至关重要.
研究的目的:
- 量化运动皮层下降驱动和自发激活 (VA) 在下肢OA的个体.
- 为了比较OA患者和健康对照者之间的VA和运动皮质反应.
主要方法:
- 按照PRISMA指南进行系统审查和元分析.
- 包括评估VA或跨磁刺激 (TMS) 反应的研究.
- 使用乔安娜·布里格斯研究所标准和GRADE证据确定性的质量评估.
主要成果:
- 包括18项低质量的研究.
- 与对照组相比,膝关节OA患者的四头骨VA损伤与对照组相比 (SMD = 0.84,低确定性).
- 在关节/膝关节OA患者中,更多症状的肢体的VA损伤较大 (SMD = 0.42,中等确定性).
结论:
- 低确定性证据表明,在膝关节OA中,四头骨VA损伤显著.
- 中等确定性证实,对于部和膝盖骨关节炎患者来说,更痛苦的肢体具有更大的VA缺陷.
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