最低抑制度的野生类型分布和流行病学截止值-实验室和临床实用性
Gunnar Kahlmeter1,2,3, John Turnidge4,5
1Technical Data Coordinator of the European Committee on Antimicrobial Susceptibility Testing (EUCAST), Växjö, Sweden.
Clinical microbiology reviews
|December 1, 2023
概括
流行病学切线值 (ECOFF) 定义了野生类型的抗菌素敏感性,作为检测耐药性发展的敏感措施. 通过ECOFF,可以在不同的测试系统和不断变化的断点之间进行标准化的比较.
科学领域:
- 微生物学 微生物学
- 抗微生物耐药性 抗微生物耐药性
- 临床实验室科学 临床实验室科学
背景情况:
- 最低抑制度 (MIC) 值是相对的,没有参考分布.
- 野生型 (WT) 微生物种群在没有耐药性的情况下表现出日志正常的MIC分布.
- 流行病学截止值 (ECOFF) 代表了WT分布的上限.
研究的目的:
- 用ECOFFs来描述野生类型的MIC和区域直径分布.
- 建立对抗微生物敏感性测试 (AST) 的参考标准.
- 为检测抗微生物药物耐药性的早期迹象提供一个敏感的措施.
主要方法:
- 统计识别单模式WT分布的上限.
- 对微生物物种和抗微生物剂的MIC和区域直径分布的分析.
- 将ECOFF与EUCAST等组织设定的临床断点进行比较.
主要成果:
- 即使存在耐药 (非WT) 种群,也可以识别ECOFF.
- ECOFF是新兴抗性的最敏感的指标.
- 在设定临床断点时,通常保持WT分布,以避免分裂主要种群.
结论:
- 在AST中解释MIC值时,ECOFF提供了一个关键的参考.
- ECOFFs有助于检测和排除耐药性.
- 通过ECOFF,可以在不同的系统,时间和医疗领域进行对抗性数据的标准化比较.
更多相关视频
09:17A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii
Published on: January 2, 2017
14.7K
09:57System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
8.7K
相关概念视频
Determination of Michaelis Constant and Maximum Elimination Rate
115
The Michaelis constant (KM) and the theoretical maximum process rate (Vmax) are vital parameters in the Michaelis-Menten equation, central to many biochemical reactions. They provide essential insights into enzyme kinetics and drug metabolism.
These parameters can be estimated by analyzing plasma concentration data post-drug administration. A notable example of this application is phenytoin, a drug with capacity-limited kinetics. It's recommended that phenytoin should be administered at two...
These parameters can be estimated by analyzing plasma concentration data post-drug administration. A notable example of this application is phenytoin, a drug with capacity-limited kinetics. It's recommended that phenytoin should be administered at two...
115
Drug Concentration Versus Time Correlation
796
The plasma drug concentration-time curve is a crucial tool in pharmacokinetics, representing the drug's concentration in plasma at different time intervals post-administration. This curve illustrates the drug's journey from absorption into the systemic circulation, distribution to body tissues, and eventual elimination through excretion or biotransformation.
Two pivotal parameters are the minimum effective concentration (MEC) and the minimum toxic concentration (MTC). The MEC is the...
Two pivotal parameters are the minimum effective concentration (MEC) and the minimum toxic concentration (MTC). The MEC is the...
796
