便calprotectin水平与有或没有炎症性肠病患者的肠道病原体检测有非线性关联
Kira L Newman1, Peter D R Higgins1
1Department of Medicine, University of Michigan , Ann Arbor, Michigan, USA.
Journal of clinical microbiology
|December 1, 2023
概括
便calprotectin (FCP) 可以表明胃肠道感染,但其升高随着炎症性肠病 (IBD) 状态而变化. 病原体检测与更高的FCP有关,特别是在非IBD患者中,这表明FCP有助于,但不能取代感染测试.
科学领域:
- 胃肠病学 胃肠病学
- 临床诊断 临床诊断 临床诊断
- 微生物学 微生物学
背景情况:
- 便calprotectin (FCP) 是炎症性肠病 (IBD) 活动的生物标志物.
- 升高的FCP水平也可能表明胃肠道感染.
- FCP,IBD状态和感染之间的关系需要进一步量化.
研究的目的:
- 量化FCP水平与实验室确认的胃肠道感染之间的关联.
- 调查这种关联在有或没有IBD的患者中是如何不同的.
- 确定FCP是否可以作为IBD患者感染的可靠指标.
主要方法:
- 横截面研究分析了FCP和胃肠病原体聚合酶链反应 (GI PCR) 测试的遭遇.
- 用于数据分析的非参数试验和量子力回归.
- 基于IBD状态和病原体检测的FCP水平的比较.
主要成果:
- 总共有3,347次遭遇被分析;54.4%的人患有IBD.
- 病原体在22.2%的遭遇中被检测到,IBD和非IBD组之间的检测率没有差异.
- 在非IBD患者中,中位数FCP在病原体检测时显著更高 (64vs41mg/kg).
- 在IBD患者中,随着病原体检测,中位数FCP没有显著升高 (299对255毫克/公斤).
- 量子回归显示,病原体检测与较低四分位数中较高的FCP相关,而IBD始终与较高的FCP相关.
结论:
- 用肠道PCR检测病原体与高FCP有关,但这种关系是非线性的,受IBD状态的影响.
- 由于感染导致的FCP升高在没有IBD的个体中更为明显.
- FCP可以作为评估胃肠道感染的辅助工具,但不应取代便病原体检测.
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