患有急性和慢性结石胆囊炎的患者的Th1/Th2细胞因子概况
1Department of Clinical Laboratory, Wenzhou Seventh People's Hospital, Wenzhou, China.
European cytokine network
|December 1, 2023
概括
这项研究发现,特定的细胞因子,包括INTERLEUKIN-6 (IL-6) 和INTERLEUKIN-10 (IL-10),与结石胆囊炎 (CC) 的严重程度有关. 这些发现表明IL-6和IL-10可以帮助评估CC进展.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 医学生物化学 医学生物化学
背景情况:
- Th1/Th2细胞因子和结石胆囊炎 (CC) 之间的关系尚不清楚.
- 了解这些免疫反应对于管理CC至关重要,包括急性 (ACC) 和慢性 (CCC) 形式.
研究的目的:
- 调查血清Th1和Th2细胞因子表达和CC之间的相关性.
- 确定潜在的细胞因子标志物,以评估急性结石胆囊炎 (ACC) 的严重程度和进展.
主要方法:
- 血清度的Th1 (IL-2,TNF-α,IFN-γ) 和Th2细胞因子 (IL-4,IL-6,IL-10) 在102名CCC患者,64名ACC患者和55名健康对照 (HCs) 使用流细胞计量测量.
- 计算了IL-6/IL-10比率,并分析了与临床参数的相关性.
- 用单变量和多变量考克斯回归分析来确定ACC严重程度的独立标志物.
主要成果:
- 与HC患者相比,CCC患者显示IL-6和IL-10的增加.
- ACC患者的IL-2,TNF-α,IL-6和IL-10水平较高,IL-6/IL-10比率增加.
- 鉴定出IL-10和IL-6是ACC严重性的独立因素,在中度至重度病例中IL-10较高. IL-2与肝酶相关,TNF-α与住院时间相关.
结论:
- 结算胆囊炎与非典型的Th1/Th2细胞因子表达特征有关.
- 介质素-6 (IL-6) 和介质素-10 (IL-10) 是评估CC的严重程度和进展的重要指标.
- 手术后,细胞因子水平下降,但没有完全正常化,这表明正在进行的炎症过程.
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