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Updated: Jul 9, 2025

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孕产妇年龄与不良妊娠结果的关联:中国的一项前性多中心队列研究
Yubo Zhou1,2, Shaohua Yin3,4,5, Qing Sheng3,5
1Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health, Peking University Health Science Center, Beijing, China.
Journal of global health
|December 1, 2023
概括
晚年母亲的年龄增加了许多不良妊娠结果的风险,特别是在第一次母亲身上. 建议在35岁之前生孩子,以优化妊娠健康.
科学领域:
- 产科和妇科 产科和妇科
- 生殖健康 生殖健康
- 流行病学 流行病学
背景情况:
- 母亲年龄是影响怀孕结果的已知因素.
- 这种关系的确切性质 (线性与曲线性) 以及其因平价性 (无双与多双) 的变化需要进一步阐明.
研究的目的:
- 描述中国妇女产妇年龄和怀孕结果之间的关系.
- 评估平价是否会改变孕产妇年龄和不良妊娠结果之间的关联.
主要方法:
- 对18495名单身孕妇进行的前性多中心队列研究.
- 限制性立方线用于建模非线性年龄结果关系.
- 多变量逻辑双项回归用于估计相对风险 (RR) 和95%置信区间 (CI).
主要成果:
- 母亲年龄与妊娠糖尿病,妊娠高血压障碍,孕前,胎盘增生谱,胎盘前,剖腹产,早产,妊娠年龄大,巨和胎儿先天异常有非线性积极关联.
- 对于35岁以上的女性来说,风险总体上更高,具体的结果在40-44岁和≥45岁的年龄组达到顶峰.
- 大多数不良结果的风险在无双的女性中比多双的女性更为明显.
结论:
- 延迟分娩与增加妊娠不良结果的风险有关.
- 这些风险在未婚妇女中特别高.
- 建议在35岁之前生孩子,以优化妊娠结果.
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