心血管功能障碍是由尼古丁吸入和高脂肪饮食的联合暴露引起的
Anna K Whitehead1,2, Zhen Li1,3, Kyle B LaPenna1,3
1Cardiovascular Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States.
American journal of physiology. Heart and circulatory physiology
|December 1, 2023
概括
尼古丁和高脂肪饮食的联合暴露会导致严重的心血管损伤. 这包括新发的心脏功能障碍和血压调节障碍,突出显示了这两种产品的用户存在不同的风险.
科学领域:
- 心血管科学 心血管科学
- 毒理学 毒理学 毒理学
- 代谢性疾病 代谢性疾病
背景情况:
- 吸烟和高脂肪饮食 (HFD) 是可修改的心血管疾病 (CV) 的风险因素.
- 由HFD引起的肥胖与增加的烟草制品使用有关.
- 尼古丁和HFD的联合心血管效应尚不清楚.
研究的目的:
- 调查尼古丁和HFD对心血管健康的联合影响.
- 为了确定组合暴露是否导致独特或附加的心血管功能障碍.
主要方法:
- 在C57BL/6N小鼠 (雄性和雌性) 暴露在尼古丁蒸汽和/或HFD中,持续10-12周.
- 通过心声学,放射测量,LV导管和血管活性测定来评估心血管功能.
- 饮食组包括HFD (60%脂肪) 和常规饮食 (22%脂肪).
主要成果:
- 结合尼古丁和HFD诱导左心室 (LV) 扩张功能障碍和增加LV末端扩张压力 (LVEDP).
- 尼古丁破坏了昼夜血压调节;HFD损害了副交感音调.
- 联合暴露加剧了依赖内皮质的血管扩张和氧化合成酶酸化.
结论:
- 结合尼古丁和HFD暴露会导致显著的心血管损伤,包括添加和新的心血管功能障碍.
- 两性都容易受到这些组合的不良影响.
- 这突显了个人消费尼古丁产品和HFD的独特心血管风险.
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