关于显式和隐式离散流行病模型稳定性的时间尺度理论:对猪流感疫情的应用
Gülşah Yeni1,2, Elvan Akın1, Naveen K Vaidya3
1Department of Mathematics and Statistics, Missouri S & T, Rolla, MO, 65409, USA.
Journal of mathematical biology
|December 1, 2023
概括
时间尺度理论为传染病动态提供了新的离散流行病模型. 隐式离散模型准确地描述了猪流感数据,有助于疫情预测.
科学领域:
- 数学生物学 数学生物学
- 流行病学 流行病学
- 动态系统 动态系统
背景情况:
- 时间尺度理论是20世纪80年代建立的,它是用于模拟宿主内部和宿主之间传染病动态的最新方法.
- 了解流行病的动态对于预测和控制疾病爆发至关重要.
研究的目的:
- 使用时间尺度方法开发明确和隐性离散流行病模型.
- 为了制定这些模型的基本复制号 (R0).
- 分析无病和特有平衡的稳定性,并用现实数据验证模型.
主要方法:
- 基于时间尺度理论的离散流行病模型的开发.
- 基本复制号的制定 (R0).
- 使用线性化和利亚普诺夫函数进行稳定性分析.
- 使用猪流感疫情数据进行申请和验证.
- 对模型参数的灵敏度分析.
主要成果:
- 成功制定了明确和隐性离散的流行病模型.
- 隐式离散模型在描述不同频率的猪流感爆发数据方面表现出卓越的准确性.
- 灵敏度分析揭示了关键参数对基本复制数的影响.
结论:
- 来自时间尺度理论的离散流行病模型可以有效地捕捉传染病的动态.
- 隐式离散模型显示了准确的实时流行病预测的前景.
- 参数灵敏度分析对于了解疾病传播驱动因素至关重要.
相关概念视频
Steps in Outbreak Investigation
133
In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
133
Parametric Survival Analysis: Weibull and Exponential Methods
448
Parametric survival analysis models survival data by assuming a specific probability distribution for the time until an event occurs. The Weibull and exponential distributions are two of the most commonly used methods in this context, due to their versatility and relatively straightforward application.
Weibull Distribution
The Weibull distribution is a flexible model used in parametric survival analysis. It can handle both increasing and decreasing hazard rates, depending on its shape parameter...
Weibull Distribution
The Weibull distribution is a flexible model used in parametric survival analysis. It can handle both increasing and decreasing hazard rates, depending on its shape parameter...
448
Survival Curves
166
Survival curves are graphical representations that depict the survival experience of a population over time, offering an intuitive way to track the proportion of individuals who remain event-free at each time point. These curves are widely used in fields such as medicine, public health, and reliability engineering to visualize and compare survival probabilities across different groups or conditions.
The Kaplan-Meier estimator is the most common method for constructing survival curves. This...
The Kaplan-Meier estimator is the most common method for constructing survival curves. This...
166
Assumptions of Survival Analysis
134
Survival models analyze the time until one or more events occur, such as death in biological organisms or failure in mechanical systems. These models are widely used across fields like medicine, biology, engineering, and public health to study time-to-event phenomena. To ensure accurate results, survival analysis relies on key assumptions and careful study design.
134
Introduction To Survival Analysis
247
Survival analysis is a statistical method used to study time-to-event data, where the "event" might represent outcomes like death, disease relapse, system failure, or recovery. A unique feature of survival data is censoring, which occurs when the event of interest has not been observed for some individuals during the study period. This requires specialized techniques to handle incomplete data effectively.
The primary goal of survival analysis is to estimate survival time—the time...
The primary goal of survival analysis is to estimate survival time—the time...
247
Hazard Rate
114
The hazard rate, also known as the hazard function or failure rate, is a statistical measure used to describe the instantaneous rate at which an event occurs, given that the event has not yet happened. From a probabilistic perspective, it represents the likelihood that a subject will experience the event in a very small time interval, conditional on surviving up to the beginning of that interval. In terms of frequency, the hazard rate can be viewed as the ratio of the number of events to the...
114


