特定营养生物标志物在预测经过选择性腹部手术的患者手术后并发症中的作用
Hemamalini Raghuraman1, Balakrishnan Gurushankari2, Giri B Laya1
1Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, 605006, India.
Langenbeck's archives of surgery
|December 1, 2023
概括
血清前白蛋白和转激素水平可以预测经过选择性腹部手术的患者的术后并发症. 通过这些营养生物标志物的早期检测,可以及时进行干预,以减少手术风险.
科学领域:
- 临床营养学 临床营养学
- 外科手术的结果
- 生物标志物发现发现
背景情况:
- 营养不良带来了术后并发症的重大风险.
- 营养生物标志物提供了对营养状况的客观评估.
- 早期识别有风险的患者对于改善手术结果至关重要.
研究的目的:
- 评估特定营养生物标志物在预测术后并发症方面的诊断效果.
- 评估像前专辑蛋白,转激素和IGF1这样的生物标志物的能力,以识别高风险患者.
- 确定这些生物标志物是否可以帮助进行手术前风险分层.
主要方法:
- 对320名接受选择性腹部手术的成年患者进行前性队列研究.
- 在入院时进行的营养生物标记测试 (前白蛋白,转移素,IGF1).
- 术后并发症使用克莱维恩-丁多分类来记录和分级.
主要成果:
- 126名患者 (39.38%) 发生了术后并发症.
- 血清前白蛋白 (<17.287 mg/dL),转激素 (<168.04 mg/dL) 和IGF1 (<44.51 ng/ml) 的较低水平与并发症发生率的增加有关 (p <0.001).
- 血清IGF1表现出最高的AUC (0.7782),对IGF1和转激素具有很高的敏感性.
结论:
- 血清前白蛋白和转激素是选择性腹部手术患者手术后并发症的有效预测剂.
- 这些生物标志物有助于在手术前识别有风险的患者.
- 使用这些生物标志物可以指导纠正措施,以潜在地降低整体术后并发症率.
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