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纹身油墨:细胞反应的评估和对一些微量金属的分析

Sumru Sozer Karadagli¹, Gizem Kaftan², Islam Cansever³

¹Faculty of Pharmacy, Department of Pharmaceutical Toxicology, Ege University, Izmir, Turkey. l.sumru.sozer@ege.edu.tr.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine

|December 1, 2023

概括

纹身油墨含有高水平的金属,如和,超过安全限制. 这些油墨降低了细胞活力,并引发炎症反应,可能导致不良健康影响.

科学领域:

毒理学毒理学毒理学
皮肤病学皮肤病学
材料科学材料科学材料科学

背景情况:

纹身油墨在应用后被保留在皮肤中.
在使用纹身之前,墨水缺乏足够的安全评估.
人们对纹身油墨成分的潜在毒性存在担忧.

研究的目的:

为了确定土耳其纹身油墨中的金属含量 (Cd,Hg,Pb,Cr).
为了研究检测到的金属水平和细胞效应之间的关系.
评估纹身油墨对细胞活力和炎症反应的影响.

主要方法:

分析了来自三个品牌的九种纹身油墨,使用ICP-MS进行元素含量分析.
在暴露于墨水后,通过WST-1试验评估人类角质细胞细胞活力.
在墨水或金属暴露后使用ELISA测量介素-18 (IL-18) 水平.

主要成果:

纹身油墨显示Cd,Hg,Pb和Cr的度各不相同,Pb和Cr超过了确定的限值.
墨水暴露降低了角质细胞细胞活力,以剂量和颜色依赖的方式.
观察到IL-18释放的显著增加,表明免疫系统的激活,除了Cr和一个黑色墨水.

结论:

土耳其的一些纹身油墨含有超过欧洲安全标准的金属度.
纹身油墨可以诱导细胞毒性作用并激活免疫系统.
这些发现突出了与常见纹身油墨相关的潜在毒理风险.

关键词:

在ICP-MS中,使用的是ICP-MS.炎症炎症是一种炎症.角质细胞 (keratinocytes) 是一种细胞.金属毒性金属毒性纹身墨水是什么意思

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