拉尔特格拉维尔加拉米武丁维持治疗的有效性和安全性
Beatriz Borjabad1, Alexy Inciarte2, Ivan Chivite2
1Internal Medicine Service, Hospital Moises Broggi, Sant Joan Despí, Spain.
The Journal of antimicrobial chemotherapy
|December 1, 2023
概括
切换到拉尔特格拉维尔和拉米武丁简化的艾滋病毒治疗方案保持了有效性,并且在病毒学上受抑制的个体中耐受良好. 这为管理艾滋病毒提供了潜在的成本效益高的选择.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 药理学 药理学是指药理学的学科.
背景情况:
- 减少药物负担对于艾滋病毒感染者 (PWH) 长期坚持治疗至关重要.
- 之前的24周数据表明,拉尔特格拉维尔加拉米武丁在简化艾滋病毒治疗方面有效且耐受良好.
- 这种简化治疗方案需要长期的疗效和安全性数据.
研究的目的:
- 为了评估转换为固定剂量 raltegravir 和 lamivudine 组合的 48 周疗效和耐受性.
- 评估这种疗法对病毒载量,艾滋病毒DNA,炎症标志物和生活质量的影响.
主要方法:
- 一个随机临床试验的48周延长,涉及病毒学上抑制的PWH.
- 参与者被随机分配到切换或继续治疗,切换组接受1200毫克/天的拉尔特格拉维尔和300毫克/天的拉米武丁.
- 主要结局是治疗失败;次要结局包括病毒载量,HIV DNA,细胞因子,身体组成和不良事件.
主要成果:
- 在48周后,治疗失败率很低,为9% (ITT) 和3% (在治疗期间).
- 一名参与者经历过短暂的病毒学失败而没有抵抗,在重新启动时实现了抑制.
- 由于副作用,两名参与者停止了治疗;观察到血清细胞因子的显著变化,但没有其他次要结局.
结论:
- 转换为拉尔特格拉维尔和拉米武丁,在病毒学上抑制的PWH中保持有效性和耐受性.
- 这种简化的治疗方案可能是对具有药物相互作用或特定毒性风险的PWH的成本有效策略.
- 进一步的研究可能会探索长期益处和更广泛的适用性.
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