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两类块共聚物PEG-b-PMTCs:合成,自组装,降解特性和生物相容性

Yiyi Deng^1,2, Sven Schäfer³, Devin Kronstein^1,2

¹Leibniz-Institut für Polymerforschung Dresden e.V., Hohe Straße 6, 01069 Dresden, Germany.

Biomacromolecules

|December 1, 2023

概括

可生物降解的纳米颗粒是从一种新型的循环基乙烯 (CKA),2-甲基-1,3,6-三干 (MTC) 中创建的. 这些基于MTC的纳米颗粒显示出高效的酶和基本水解降解,以及用于药物输送的优良生物相容性.

科学领域:

聚合物科学聚合物科学
材料科学材料科学材料科学
生物医学工程生物医学工程

背景情况:

循环乙烯 (CKAs) 正因其可调节的降解特性而受到关注.
2-甲基-1,3,6-trioxocane (MTC) 是一种具有增强生物降解性的爱水性CKA.
两类块共聚合物对基于纳米粒子的药物输送系统具有前景.

研究的目的:

合成和表征基于聚MTC的两类块共聚合物.
从这些共聚合物中形成和分析纳米粒子,用于药物输送应用.
评估基于MTC的纳米颗粒的降解概况和生物相容性.

主要方法:

激环开放聚合制造,以制造聚-MTC块共聚合物.
在PBS缓冲器中自组装形成纳米粒子,其特点是DLS,TEM和SLS.
使用尼罗河红载纳米粒子和光谱学进行酶降解研究.
在基本条件下的水解降解和对HEK293细胞的细胞毒性测定.

主要成果:

成功制备了大小从40到105纳米的两性多MTC纳米粒子.
来自*Pseudomonas cepacia*的脂酶证明了纳米颗粒的高效酶降解.
在基本水解条件下,在4小时内实现了完整的降解.
细胞毒性测定证实高细胞活力 (>90%) 在纳米颗粒度高达1毫克/毫升.

结论:

基于MTC的两类块共聚合物可以形成稳定,可生物降解的纳米粒子.
纳米粒子通过酶和水解途径呈现快速降解.
这些基于MTC的纳米粒子是生物相容的,适合潜在的药物输送应用.

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