流体动力学改变了封闭的水性双相系统中的液态-液态相隔
Eric W Hester1,2, Sean Carney1,2, Vishwesh Shah3
1Department of Mathematics, University of California, Los Angeles 90095, CA.
概括
在水性双相系统 (ATPS) 中,液态-液态相分离对于生物学和医学至关重要. 流体动力学,包括浮力,显著影响滴滴的形状和形成,导致优化微粒的生产.
科学领域:
- 生物物理学的生物物理.
- 材料科学 材料科学 材料科学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 液-液相分离 (LLPS) 是细胞组织和生物技术应用的基础.
- 在水性双相系统 (ATPS) 中控制滴状形态使单细胞分析,药物输送和组织工程的进步成为可能.
- 以前的模型往往忽视了流体动力学,可能会误解相位分离行为.
研究的目的:
- 在ATPS中开发LLPS的计算模型,该模型包含流体动力学.
- 研究浮力,表面张力和剪切流对相位分离动力学和形态学的影响.
- 为了更准确地了解ATPS演变,以优化微粒子生产和生物应用.
主要方法:
- 开发了一个模拟有限粘度流体动力学与热诱导相位分离的计算模型.
- 在模型中包括浮力和表面张力效应.
- 将模型预测与凝-聚乙烯糖醇混合物的实验数据进行比较.
主要成果:
- 流体动力学显著改变了相位分离的演变和平衡.
- 浮力驱动ATPS向能量最小化的新月形状,与忽视流体动力学的模型相矛盾.
- 剪切流可以将粒子形成加速十倍.
- 忽视流体动力学导致对最小能量滴滴形状的不准确预测.
结论:
- 准确的ATPS建模需要结合流体动力学,特别是浮力.
- 开发的模型增强了对生物和工业环境中的微粒子形成和ATPS行为的理解.
- 这项工作有助于优化结构化微粒的制造工艺,并提高了对细胞细分的洞察力.
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