菲律宾5型人类腺病毒中和抗体的血清流行率
Abialbon G Francisco1, John Carlo B Reyes2, Ian Kim B Tabios3,4
1Department of Medical Microbiology, College of Public Health, University of the Philippines Manila, Manila, Philippines.
PloS one
|December 1, 2023
概括
在菲律宾发现了对5型人类腺病毒 (HAdV-5) 的高高的原有免疫力. 这种广泛的免疫力需要适应性疫苗接种策略,以获得有效的腺病毒载体疫苗.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 人类腺病毒5型 (HAdV-5) 由于其免疫性和安全性,是疫苗开发的关键载体.
- 对HAdV-5的预先存在的中和抗体 (NAbs) 可以显著阻碍腺病毒载体疫苗的疗效.
- 了解HAdV-5 NAb血清流行率对于设计有效的疫苗接种计划至关重要.
研究的目的:
- 确定对菲律宾5型人类腺病毒 (HAdV-5) 中和抗体 (NAbs) 的血清流行率.
- 评估先前存在的HAdV-5免疫对潜在的腺病毒载体疫苗策略的影响.
- 为了确定HAdV-5 NAb血清流行率的区域变异.
主要方法:
- 使用基于 luciferase 的中和试验来检测和量化 HAdV-5 NAbs.
- 分析了菲律宾城市和农村地区的391个血/血清样本.
- 确定了对HAdV-5的血清流行率和抗体标位.
主要成果:
- 在研究人群中观察到HAdV-5 NAbs的高血清流行率为88.5%.
- 大多数阳性样本 (56.8%) 表现出高的NAb标位对HAdV-5.
- 比科尔 (V地区) 的血清流行率最高,为94.1%.
结论:
- 菲律宾成年人口中很大一部分人对HAdV-5具有先前存在的免疫力.
- 菲律宾的腺病毒载体疫苗策略应考虑到高HAdV-5 NAb水平.
- 建议考虑主要增强疗法或额外的增强剂量来克服先前存在的免疫力.
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