与聚乙烯微塑料相比,聚乳酸微塑料在成长中的小鼠中没有表现出较低的生物毒性
Yongfeng Deng1, Pan Yang2, Hongli Tan3
1Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China.
Journal of agricultural and food chemistry
|December 1, 2023
概括
像聚乳酸 (PLA) 这样的生物塑料会产生对健康构成风险的微塑料 (MP). 与PVC-MP相比,PLA-MPs在小鼠中显示出更大的体重增加抑制和肠道失调,挑战了生物塑料安全假设.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 材料科学 材料科学 材料科学
背景情况:
- 生物塑料,如聚乳酸 (PLA),越来越多地用于食品包装.
- 生物塑料的降解产生生物微塑料 (BMP),可以通过摄入进入人体.
- 与BMPs相关的体内健康风险在很大程度上是未知的.
研究的目的:
- 在成长中的小鼠中比较聚乳酸微塑料 (PLA-MPs) 和聚乙烯微塑料 (PVC-MPs) 的毒性.
- 研究PLA-MPs和PVC-MPs对体重增加,氧化应激,基因表达,脂质代谢和肠道微生物群的健康影响.
主要方法:
- 在成长中的小鼠暴露于不规则形状的PLA-MPs (16-350μm) 和PVC-MPs (40-300μm) 六周.
- 评估体重增加,氧化应激标志物,肝脏和结肠的转录特征 (基因表达).
- 分析脂质代谢,消化系统的影响,以及肠道微生物群的组成和多样性.
主要成果:
- 与PVC-MPs相比,PLA-MP暴露导致了更显著的体重增加抑制.
- 无论是PLA-MP还是PVC-MP,都提高了氧化应激水平,并在肝脏和结肠中改变了基因表达.
- PLA-MPs对脂质新陈代谢,消化系统产生更强烈的影响,并导致肠道微生物群失调.
结论:
- 在成长中的小鼠中,PLA-MPs的毒性与常规PVC-MPs的毒性相当,在某些方面甚至超过.
- 这些发现需要重新评估生物塑料的安全性,特别是关于微塑料的形成和相关的健康风险.
- 生物塑料安全评估应考虑产生微塑料的可能性及其毒理影响.
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