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针对epCAM的CAR-T细胞免疫疗法对上皮质瘤是安全有效的

Dan Li¹, Xianling Guo², Kun Yang³

¹Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Science advances

|December 1, 2023

概括

针对EpCAM的化学抗原受体T细胞 (CAR-T) 疗法在固体瘤中显示出前景. 临床前和临床研究表明,EpCAM-CAR-T细胞是可行的和可以容忍的,一些患者实现了部分反应和延长无进展的生存时间.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
细胞疗法细胞疗法

背景情况:

在固体瘤中,CAR-T细胞疗法已显示出有限的疗效.
表皮细胞粘附分子 (EpCAM) 是表皮细胞瘤的一个有前途的生物标志物.
针对EpCAM的CAR-T疗法的临床应用尚未得到充分发展.

研究的目的:

调查EpCAM-CAR-T细胞对固体瘤的临床前和临床疗效和安全性.
为了评估Dectin-1被刺激的EpCAM-CAR-T细胞的抗瘤活性和耐受性.

主要方法:

在异种移植小鼠模型和EpCAM人性化小鼠中进行临床前研究.
在患上上皮质瘤的患者中进行临床研究 (NCT02915445).
对抗瘤活性,毒性和无进展生存率的评估.

主要成果:

在小鼠模型中,EpCAM-CAR-T细胞表现出强大的抗瘤活性,没有任何不良影响.
在临床试验中,50%的患者患有自我缓解的1/2级毒性,8.3%患有可逆的3级白血病.
两名患者实现了部分反应,三名患者的无进展生存期超过23个月,其中一人患有2年的PFS.

结论:

对于固体瘤,EpCAM-CAR-T细胞疗法是可行的和可以容忍的.
德克丁-1辅助刺激增强了EpCAM-CAR-T细胞的抗瘤活性.
这项研究支持EpCAM-CAR-T治疗上皮质恶性瘤的进一步临床开发.

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