雷米马佐拉姆剂量用于胃镜检查:一个随机的非劣势性试验
Huichen Zhu1, Zhongxue Su1, Hongmei Zhou2
1Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Anesthesiology
|December 1, 2023
概括
雷米马佐拉姆在0.2mg/kg的剂量为胃镜检查提供了与普罗波相比不低劣的镇静作用,并减少了不良事件. 0.15 mg/kg的剂量较低,强调了这种超短效剂的适当剂量的重要性.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 胃肠病学 胃肠病学
背景情况:
- 雷米马佐拉姆是一种超短暂作用的二甲,具有内镜镇静的潜力.
- 体重影响镇静的深度,需要基于体重的剂量考虑.
- 在胃镜镇静中比较雷米扎洛拉姆和普罗波的疗效和安全性至关重要.
研究的目的:
- 为了比较基于体重的不同剂量的雷米马佐拉姆与托福尔在胃镜检查期间镇静的疗效和安全性.
- 根据镇静成功率,确定雷米马佐拉姆与普罗波福的非劣质性.
主要方法:
- 一个多中心的,随机的,单盲的,并行控制的非劣等性试验.
- 接受胃镜检查的1883名患者被随机分配给接受0.15毫克/千克雷米马佐拉姆,0.2毫克/千克雷米马佐拉姆或1.5毫克/千克普罗波.
- 主要结局是镇静成功率;对不良事件进行了监测.
主要成果:
- 治疗0.2mg/kg的雷米马佐拉姆组 (98.7%) 与治疗普罗波福尔 (99.4%) 相比,表现出非劣质镇静成功.
- 在镇静成功方面,0.15 mg/kg 雷米马佐拉姆组 (88.5%) 低于普罗波福尔 (99.4%).
- 雷米马佐拉姆组的不良事件发生率显著降低,包括胸肌梗塞,低血压和呼吸系统抑郁.
结论:
- 雷米马佐拉姆在0.2mg/kg的剂量对于胃镜镇静效果与普罗波福不逊色.
- 发现较低的雷米马佐拉姆剂量 (0.15 mg/kg) 的效果较差.
- 在这种情况下,雷米马兰与普罗波相比,具有更高的安全性.
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