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在子宫内暴露于聚二 (PBB) 和月经周期功能在成年期

Suman Barat¹, Robert B Hood², Metrecia L Terrell²

¹Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.

International journal of hygiene and environmental health

|December 1, 2023

概括

产前暴露于多二 (PBBs) 与女性在黄体阶段的更高的孕激素水平有关. 大多数其他月经周期特征不受PBB暴露的影响.

科学领域:

环境健康环境健康
生殖流行病学生殖流行病学
毒理学毒理学毒理学

背景情况:

聚二 (PBBs) 是环境污染物,已知与不良生殖结果有关,包括改变青春期时间.
关于子宫内PBB暴露对成人月经周期功能和生殖激素水平的影响的数据有限.

研究的目的:

调查子宫内聚二 (PBB) 暴露与生育年龄妇女的月经周期特征之间的关联.
评估PBB暴露水平与特定的生殖激素代谢物 (雌激素3 - 葡萄胺,孕妇二醇3 - 葡萄胺) 和卵泡刺激激素 (FSH) 之间的关系.

主要方法:

分析了密歇根州 PBB 登记册中 41 名女性的数据,记录了她们在子宫内接触 PBB 的情况.
通过母体血清PBB水平和PBB消除模型估计子宫内PBB暴露.
在长达6个月的时间里,每天检测尿液样本中的雌激素3-葡萄糖化物 (E13G),孕妇二醇3-葡萄糖化物 (Pd3G) 和FSH.

主要成果:

与暴露较低的女性相比,在子宫内PBB暴露较高的女性显示出显著增加的最大3天平均黄体期孕二醇3-葡萄化物 (Pd3G) 水平.
具体来说,随着子宫内PBB暴露类别的增加 (1.0-3.0ppb和>3.0ppb),质阶段Pd3G水平增加.
在子宫内PBB暴露与平均周期长度,卵泡或质阶段长度,出血长度,E13G或FSH水平之间没有发现显著的关联.

结论:

较高的子宫内PBB暴露与月经周期黄质期期间的孕激素代谢物水平增加有关.
在这个队列中,大多数其他月经周期参数与子宫内PBB暴露没有显著关联.
由于研究的样本规模较小,应谨慎解释结果.

关键词:

双化合物是一种双化合物.制阻燃剂是一种制阻燃剂.月经周期月经周期.聚胺双烯酸是多的孕激素 (Progesterone) 是一种激素.这是一项两代人的研究.

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