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饮食中的黄类药物可能在帕金森病中具有保护性和治疗性作用:系统性审查

Christian Adrián González-May¹, María Del Rosario Barradas-Castillo¹, Javier Humberto Perera-Rios¹

¹Facultad de Medicina, Universidad Autónoma de Yucatán, Centro, 97000, Mérida, Yucatán, México.

Nutrition research (New York, N.Y.)

|December 1, 2023

概括

聚醇,像水果和蔬菜中发现的黄类,可能会降低帕金森病 (PD) 的风险和死亡率. 某些富含多的食物和补充剂显示出改善PD患者运动功能的潜力.

科学领域:

神经科学是一个神经科学.
营养科学营养科学
流行病学流行病学

背景情况:

帕金森病 (PD) 涉及由于氧化应激和神经炎症而导致的多巴胺基神经元损失.
聚醇,特别是植物性食品中丰富的黄类,具有抗氧化特性,可以提供神经保护.
现有的临床和队列研究表明,多醇消费与PD风险或进展之间存在联系.

研究的目的:

系统地审查随机对照试验和关于在帕金森病中使用多的队列研究.
在PD管理中整合科学证据对潜在的饮食建议.

主要方法:

在PubMed,Science Direct,Scielo和Web of Science数据库中系统地搜索文献.
在选1100个初始记录后,包括5项研究 (3项RCT,2项队列研究).
分析了摄入的多 (黄,) 和特定的食物消费 (果,果,红葡萄酒).

主要成果:

黄酸盐,酸盐和特定食物 (果,红葡萄酒,果) 的摄入与PD风险和死亡率的降低相关.
用甘,黄素或可可治疗改善了PD患者的运动功能.
没有观察到对生活质量,疾病进展或非运动症状 (认知,情绪) 的显著影响.

结论:

饮食中摄入某些多和富含多的食物可能会降低帕金森病的风险和死亡率.
特定的多源在改善PD的运动症状方面表现有前途.
进一步的临床研究对于验证PD中特定多的神经保护作用至关重要.

关键词:

安托氨酸是一种安托氨酸.多巴胺是一种多巴胺.运动障碍运动障碍氧化压力是一种氧化压力.聚醇是一种多醇.

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