[阿尔茨海默病的神经心理差异取决于发病年龄]

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Beatriz Echeveste¹, Paula Tellechea², Genoveva Montoya¹

¹Servicio de Neurología, Clínica Universidad de Navarra, Navarra, España.

Revista espanola de geriatria y gerontologia

|December 1, 2023

概括

早期阿尔茨海默病 (EOAD) 患者表现出较差的注意力和执行功能,而老年阿尔茨海默病 (AD) 患者表现出更大的记忆和语言缺陷. 非常晚发的AD患者具有明显的语义流性和命名障碍.

科学领域:

神经学神经学
神经心理学神经心理学
老年病的医生老年病的医生

背景情况:

阿尔茨海默病 (AD) 通常分为早期发病 (EOAD) 和晚发病 (LOAD) 形式.
对不同发病年龄的阿尔茨海默病群体中神经心理学概况进行比较的研究,包括非常晚发病的阿尔茨海默病 (VLOAD),是有限的.
对于EOAD,65岁的年龄限制是任意的,需要对不同的临床表现进行进一步调查.

研究的目的:

为了比较早期发病的AD (EOAD),晚发病的AD (LOAD) 和非常晚发病的AD (VLOAD) 的患者的神经心理特征.
研究基于AD发病年龄的认知缺陷的潜在差异.

主要方法:

对359名可能患有AD痴呆症的患者进行了回顾性分析.
根据发病年龄,患者被分为三个组:EOAD (<65岁),LOAD (65-80岁) 和VLOAD (>80岁).
在这三个组中,神经心理测试结果进行了比较.

主要成果:

与老年人群相比,EOAD患者在注意力,执行功能和视觉空间技能方面的表现较差.
LOAD患者在记忆和语言任务方面表现出更大的缺陷.
与LOAD患者相比,VLOAD患者在语义流性和命名方面表现出更显著的损害.

结论:

在EOAD,LOAD和VLOAD患者之间存在显著的神经心理差异.
虽然有区别,但这些差异似乎代表了随年龄增长的线性趋势,而不是完全独立的临床实体.
这些发现强调了考虑发病年龄在理解AD异质性的重要性.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的疾病早期开始的AD.患有阿尔茨海默氏症的人.提前开始提前开始延迟启动时间晚期发病的阿尔茨海默病.神经心理学神经心理学神经心理学神经心理学

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