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在非喘肥胖青少年的下呼吸道的益炎模式
Desiree Gutmann1, Melanie Dressler1, Olaf Eickmeier1
1Department for Children and Adolescents, Division of Allergology, Pulmonology and Cystic Fibrosis, Goethe University, Frankfurt.
青少年的肥胖与支气管炎症的增加有关,这可以通过更高的炎症细胞和唾液中的特定基因表达来证明. 这表明肥胖可能会导致这个年龄段的呼吸道疾病.
科学领域:
- 肺部医学 肺部医学
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
背景情况:
- 肥胖是一种促炎症的疾病,影响多个器官.
- 肥胖引起的全身炎症可能与青少年的支气管炎症相关.
- 这项研究侧重于非吸烟的青少年,他们的体重指数 (BMI) ≥30公斤/平方米,没有其他慢性疾病.
研究的目的:
- 为了研究肥胖青少年的支气管炎症.
- 为了比较肥胖与非肥胖青少年的炎症标志物.
- 探索肥胖和呼吸道炎症标志物之间的关系.
主要方法:
- 将20名非喘肥胖青少年 (BMI 35.0 kg/m2) 与20名健康对照 (BMI 21.5 kg/m2) 进行了比较.
- 评估诱导的唾液差异细胞计数和mRNA水平.
- 测量了血清C反应蛋白 (CRP),IN-6 (IL-6) 和IL-8;分析了各种细胞因子和转录因子的唾液蛋白水平.
主要成果:
- 与对照人群相比,肥胖青少年的血清CRP水平,吐炎症细胞负荷和吐乙氨基酸水平显著提高.
- 唾液中性粒细胞与BMI≥30 kg/m2相关.
- 观察到IL6,IL8,IL13,IL17,IL23,IFN-γ和转录因子T-bet,GATA3和FoxP3.3的唾液mRNA表达的显著差异.
结论:
- 肥胖与青少年的支气管炎症增加有关.
- 肥胖的全身或局部炎症影响可能引发呼吸道炎症.
- 这种炎症可以解释肥胖青少年呼吸道疾病的更高率.
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