拉巴胺在调节炎性心血管疾病中的巨细胞功能的机制标
MariaSanta C Mangione1, Jinhua Wen1, Dian J Cao2
1Department of Internal Medicine, Cardiology Division, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Journal of molecular and cellular cardiology
|December 1, 2023
概括
拉巴胺素 (mTOR) 途径的机械性标调节衰老和炎症. 这篇评论探讨了mTOR的研究.
科学领域:
- 细胞生物学和分子医学
- 免疫学和炎症 免疫学和炎症
- 心血管疾病的发病源是心血管疾病的发病源.
背景情况:
- 拉巴胺素 (mTOR) 途径的机械性标是细胞过程的基本调节者,包括生长,新陈代谢和衰老.
- 失调的mTOR信号与各种疾病有关,特别是癌症,并且越来越多地被认为是心血管疾病中的作用.
- 天生的免疫反应在心血管疾病的发病过程中至关重要,mTOR发挥着关键的调节作用.
研究的目的:
- 在急性炎症 (缺血症) 和慢性炎症性心血管疾病期间审查mTOR在巨细胞功能中的调节作用.
- 在心血管健康的背景下,讨论mTOR在训练免疫力,免疫衰老和克隆性血液形成中的参与.
- 提供对mTOR路径架构,复杂功能和激活信号的最新理解.
主要方法:
- 文献综述综合了关于炎症和心血管疾病中mTOR信号传导的当前知识.
- 讨论mTOR在特定疾病中的作用,如动脉样硬化心血管疾病 (ASCVD) 和心力衰竭与保留射出分数 (HFpEF).
- 探索mTOR参与免疫现象的探索,例如训练免疫和免疫衰老.
主要成果:
- 在ASCVD和HFpEF中,mTOR在急性炎症对缺血和慢性炎症的反应中关键调节巨细胞功能.
- mTOR影响关键的免疫过程,包括训练免疫,免疫衰老和克隆血液形成,所有这些都与衰老和心血管疾病有关.
- 该审查详细介绍了mTOR的结构部件,复杂功能以及控制其激活的信号通路.
结论:
- mTOR是心血管疾病中炎症和免疫的中心调节者,特别是与衰老相关的疾病.
- 了解mTOR复杂的作用为针对心血管衰老和炎症的治疗干预打开了道路.
- 未来的研究应该专注于利用mTOR抑制剂用于与年龄有关的心血管疾病的创新治疗方法.
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