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在 (Galea spixii) 胎儿的丸和上皮膜分化过程中,形状组分和类固醇的参数

Júlia Moreira Silveira¹, Amilton Cesar Dos Santos¹, Danielle Cristina Calado de Brito¹

¹Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.

Reproductive biology

|December 1, 2023

概括

这项研究揭示了鱼的关键产前发育模式,显示了丸和副膜结构的形成以及类固醇酶和受体如何影响男性性发育.

科学领域:

生殖生物学生殖生物学
发展生物学发展生物学
内分泌学在内分泌学.

背景情况:

性差异化和类固醇生成对于男性表型的发展至关重要.
了解产前性腺发育为生殖健康提供了洞察力.

研究的目的:

为了调查产前形态和组织测量丸腔和部的发展.
为了分析关键蛋白质和酶的表达,参与体发育期间的雄激素合成.

主要方法:

男性胎的组织学和组织学分析 (25,30,40,50天).
对5α-减少酶,17β-HSD,雄激素受体和抗穆勒尔激素 (AMH) 的免疫组织化学.

主要成果:

30日形成的精髓;50日分化了生殖.
显著的与年龄相关的生殖和腹膜管径的显著增加.
在塞尔托利和莱迪格细胞中AMH的表达;在莱迪格细胞和皮层上皮质中5α-减少酶,17β-HSD和雄激素受体.

结论:

产前丸腔和副丸的发育涉及特定的形态和细胞变化.
类固醇酶和雄激素受体在丸腔和膜发育中起着至关重要的作用.

关键词:

在17β-HSDD中.5α-减少酶的使用.雄激素受体的受体雄激素受体抗米勒尔激素是一种抗米勒尔激素.动物动物

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