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ALK抑制剂增加ALK的表达,并使神经母细胞瘤细胞对ALK.CAR-T细胞敏感

Elisa Bergaggio1, Wei-Tien Tai1, Andrea Aroldi2

  • 1Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Cancer cell
|December 1, 2023
PubMed
概括

化学抗原受体 (CAR) 的T细胞向形淋巴瘤激酶 (ALK) 显示出神经母细胞瘤的前景. 将ALK抑制剂与ALK.CAR-T细胞结合起来,可提高ALK表达低的瘤的疗效.

关键词:
阿尔克 (ALK) 是一个收养的T细胞疗法细胞工程 细胞工程细胞免疫力 细胞免疫力嵌合式抗原受体 嵌合式抗原受体洛拉提尼布 (lorlatinib) 是一种药物.神经母细胞瘤的神经母细胞瘤固体瘤是一种固体瘤.铁氨基激酶抑制剂 铁氨基激酶抑制剂

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