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女人中的雄激素类固醇过量
Daphné Karila1, Véronique Kerlan2, Sophie Christin-Maitre1
1Service d'endocrinologie, diabétologie et médecine de la reproduction, hôpital Saint-Antoine, Assistance publique-Hôpitaux de Paris, 75012 Paris, France; Sorbonne université, 75006 Paris, France.
Annales d'endocrinologie
|December 1, 2023
概括
类固醇类固醇 (AAS) 增强运动表现,但会带来严重的健康风险,包括心血管问题. 它们的使用,特别是在女性中,被低估了,并构成了公共卫生挑战,需要更大的意识和预防努力.
科学领域:
- 运动医学 运动医学
- 内分泌学 在内分泌学.
- 心血管健康 心血管健康
背景情况:
- 类固醇类固醇 (AAS) 的使用在专业和业余体育运动中都在增加.
- 虽然在男性中普遍存在,但AAS使用也影响女性,估计患病率为1.6%.
- 自2014年以来,一个"类固醇护照"系统监测运动员的类固醇水平.
研究的目的:
- 为了突出体育运动中AAS使用的日益增长的患病率和健康影响.
- 为了解决缺乏关于女性运动员AAS影响的数据.
- 强调将AAS使用作为公共卫生问题被低估,特别是在女性中.
主要方法:
- 使用液体染色学和质谱学对尿液和血液中类固醇水平的纵向监测.
- 对运动员AAS影响现有数据的审查.
- 对女性运动员月经周期干扰的分析,与高雄性质有关.
主要成果:
- 过量的AAS促进肌肉生长和表现,但会引起诸如心肌缩,脂质代谢变化和血栓前状态等不良影响.
- 使用AAS与动脉样硬化和心血管事件的风险增加有关.
- 运动员女性的月经不规则 (低月经和 amenorrhea) 可能是高雄性质的结果,包括AAS使用.
结论:
- 在体育运动中使用AAS会带来相当大的心血管和代谢风险.
- 对女性运动员AAS的影响,特别是生殖健康的影响,研究不足,可能被低估.
- 医疗保健专业人员在预防AAS滥用和管理其健康后果方面面临着重大挑战,特别是在女性中.
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