摄入石榴对成年人肝功能酶的影响:系统性审查和元分析
Hossein Bahari1, Hossein Rafiei2, Kian Goudarzi3
1Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Complementary therapies in medicine
|December 1, 2023
概括
石榴的消费显著降低了AST,ALT和GGT等肝酶,特别是在肥胖或代谢障碍的人长期使用时. 需要对多醇含量进行进一步的研究.
科学领域:
- 营养科学 营养科学
- 临床医学 临床医学
- 生物化学 生物化学
背景情况:
- 肝酶升高通常表明肝损伤,特别是在肥胖和代谢障碍的人群中.
- 石榴的潜在肝脏保护作用需要通过严格的科学分析进行调查.
研究的目的:
- 进行关于石榴对肝酶影响的临床试验的系统审查和元分析.
- 为了准确估计石榴在各种临床条件中的作用.
主要方法:
- 在PubMed,Web of Science和Scopus的系统文献搜索,直到2023年3月为符合条件的随机临床试验 (RCT).
- 使用I2统计和应用随机效应模型对异质性的分析.
- 聚合数据确定为加权平均差异与95%的置信区间.
主要成果:
- 包括9个涉及3811个记录的RCT,并指出干预细节的异质性.
- 在长期干预 (>8周) 或患有代谢障碍的患者中,石榴摄入量显著降低了阿斯巴酸氨基转移酶 (AST) 和氨基转移酶 (ALT).
- 观察到马-氨基转移酶 (GGT) 的显著降低 (WMD: -5.43 IU/L). 在AST和ALT试验中发现了出版偏差.
结论:
- 长期摄入石榴可能会改善肥胖和代谢障碍的成年人的肝酶.
- 该研究强调了潜在的益处,但也承认了局限性,包括石榴产品特征的变化 (多,抗氧化剂).
- 进一步的研究应该标准化石榴干预措施,并评估特定的生物活性化合物效应.
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