可以注射的水凝嵌入了素纳米颗粒,涂上了氨酸,用于连续释放双重药物
Yongfei Zhang1, Depeng Shi2, Wenqian Wang3
1College of Materials Science and Engineering, Qingdao University, Qingdao, Shandong 266071, China.
International journal of biological macromolecules
|December 1, 2023
概括
这项研究开发了可注射的水凝,用于精确的连续药物输送,这对于治疗急性视网膜亡 (ARN) 等疾病至关重要. 新的HA-DEX-CS-NPs/GCV-Gel系统展示了受控释放,提供了潜在的治疗益处.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 眼科 治疗学 治疗学
背景情况:
- 像急性视网膜亡 (ARN) 这样的疾病的有效治疗通常需要连续服用多种药物.
- 实现精确的,长期的连续药物释放仍然是开发组合疗法的关键挑战.
研究的目的:
- 开发可注射的水凝,能够精确的连续和长期释放双重药物.
- 调查新型水凝配方中甲 (DEX) 和甘西克洛维尔 (GCV) 的释放特征.
主要方法:
- 用氨酸 (HA) 涂覆的奇托桑纳米颗粒 (CS-NPs) 被嵌入在阿尔德海德β-环氧化 (ACD) /氨基酸氨酸 (NHA) 水凝中.
- 用双重药物 (DEX-CS-NPs/GCV-Gel和HA-DEX-CS-NPs/GCV-Gel) 装载的注射用水凝进行了合成和表征.
- 评估了药物释放动力学,风湿学,凝时间,降解和细胞相容性.
主要成果:
- 该HA-DEX-CS-NPs/GCV-Gel配方表现出独特的初始滞后阶段 (7小时),没有DEX释放,表明精确的顺序释放.
- 从HA-DEX-CS-NPs/GCV-Gel中释放的DEX在前48小时内与DEX-CS-NPs/GCV-Gel相比显著缓慢.
- 复合水凝显示出合适的风湿性质,凝时间,降解行为和出色的细胞兼容性.
结论:
- 开发的可注射水凝可实现精确的顺序和长期的药物释放.
- 这项技术在治疗需要复杂,多阶段药物管理方案的疾病方面具有重大潜力.
- 这种新的水凝系统为先进的组合疗法提供了一个有前途的平台.
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