儿童和青少年黑色素瘤的风险因素和结果:一个回顾性多中心研究
Elena B Hawryluk1, Danna Moustafa2, Kelly K Barry3
1Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts; Dermatology Section, Division of Immunology, Boston Children's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.
Journal of the American Academy of Dermatology
|December 1, 2023
概括
儿科黑色素瘤与成人病例不同,表现出各种各样的亚型和结果. 青少年患有黑色素瘤的患者更有可能有家族病史.
科学领域:
- 皮肤病学 皮肤病学
- 儿科瘤学 儿科瘤学
- 癌症研究 癌症研究
背景情况:
- 儿科黑色素瘤表现出独特的临床特征,使其与成人黑色素瘤区别开来.
- 了解这些区别对于准确的诊断和治疗至关重要.
研究的目的:
- 确定与儿科黑色素瘤相关的风险因素和不良结果.
- 描述年轻黑色素瘤患者的临床表现和预后指标.
主要方法:
- 进行了一项多中心回顾性研究,涉及317名被诊断患有黑色素瘤的20岁以下患者.
- 在1995年1月1日至2015年6月30日期间,从11个学术医疗中心收集了数据.
主要成果:
- 大多数儿科黑色素瘤病例 (73%) 发生在青少年 (年龄≥11岁) 中.
- 常见的亚型包括Spitzoid (31%) 和表面传播 (26%). 在11%的病例中,先天性瘤是原因.
- 哨兵淋巴结活检在46%的病例中呈阳性,整体死亡率为7%. 青少年患者的黑色素瘤家族病史发生率较高 (P = .046).
结论:
- 儿科黑色素瘤具有不同的临床特征和结果.
- 对这些病例的更好理解对于改善儿科黑色素瘤风险分层和管理策略至关重要.
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