相关实验视频

Updated: Jul 9, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

氧化高密度脂蛋白与心房动有关

Nikolaos Pagonas¹, Rhea Mueller², Linda Weiland³

¹Department of Cardiology, University Hospital Ruppin-Brandenburg, Medical School Theodor Fontane, Neuruppin, Germany; Faculty of Health Sciences, Joint Faculty of the Brandenburg University of Technology Cottbus-Senftenberg, The (MHB) Theodor Fontane and the University of Potsdam, Potsdam, Germany.

|December 1, 2023

概括

高密度脂蛋白 (HDL) 的抗氧化功能降低与心房动 (AF) 有关. 这一发现表明,HDL功能受损可能导致这种常见心律不整的发展.

科学领域:

心脏病学心脏病学
生物化学生物化学
分子医学是分子医学.

背景情况:

心房动 (AF) 是一种普遍的慢性心律失常,与死亡率的增加有关.
新出现的证据表明,炎症,氧化应激和AF之间存在联系.
功能障碍的高密度脂蛋白 (HDL) 可能因其对心肌细胞的影响而起到AF发展的作用.

研究的目的:

调查HDL抗氧化功能降低与AF存在之间的关联.

主要方法:

一项涉及1206名参与者的多中心横截面研究.
参与者被分为AF (n=233) 和没有AF (n=973) 组.
评估HDL抗氧化功能使用测量正常化HDL脂质过氧化物含量 (nHDLox) 的无细胞试验.

主要成果:

与那些没有AF的人相比,患有AF的人的相对nHDLox平均值高出9% (P=.025).
在逻辑回归模型中,nHDLox与AF显著相关,即使经过关键风险因素调整 (所有P≤.01).

结论:

缺陷的HDL抗氧化功能与AF的存在有关.
这支持了假设,脂蛋白功能障碍有助于AF中见到的心肌细胞的电生理学变化.
升高的nHDLox被确定为AF开始和进展的促成因素.

关键词:

心房动是一种心房动.高密度脂蛋白的功能高密度脂蛋白的功能.炎症炎症是一种炎症.脂质过氧化是一种过氧化.氧化应激是一种氧化应激.

更多相关视频

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

相关概念视频

Inflammation

Inflammation

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...