调节益生菌食物来源影响炎症和免疫调节肠道微生物和代谢物:来自BE GONE试验的见解
Xiaotao Zhang1, Ehsan Irajizad2, Kristi L Hoffman3
1Division of Cancer Prevention and Population Sciences, Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Institute for Translational Epidemiology & Division of Liver Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
EBioMedicine
|December 1, 2023
概括
将豆类添加到饮食中显著增强了高风险患者的肠道微生物群多样性和有益细菌. 这些益生菌对肠道健康的影响也影响了宿主代谢和炎症标志物.
科学领域:
- 营养科学 营养科学
- 微生物组研究 微生物组研究
- 胃肠病学 胃肠病学
背景情况:
- 可获得的益生菌食物可以改善高风险个体的肠道和代谢健康.
- BE GONE试验调查了豆类消费对肥胖患者与结直肠瘤病史的影响.
研究的目的:
- 评估每日豆干预对高风险患者肠道微生物群和循环代谢物的影响.
- 在8周内评估肠道微生物多样性,细菌组成和宿主相关标记物的变化.
主要方法:
- 在MD安德森癌症中心的一项随机交叉饮食干预试验.
- 患者食用他们通常的饮食,每天或不含一杯豆子,经过8周的交叉期.
- 每4周收集一次便和血液样本,以分析肠道微生物群和循环中的代谢物.
主要成果:
- 豆类的消费增加了肠道微生物群的多样性和有益的细菌 (Faecalibacterium,Eubacterium,Bifidobacterium).
- 代谢分析显示,皮佩科利克酸增加,英多尔减少,与宿主标记物平行移位.
- 蛋白质生物标志物表明纤维细胞生长因子-19的增加和互白素-10受体α的减少,这表明炎症反应的调节.
结论:
- 豆类充当益生菌,增强肠道微生物群,调节与代谢肥胖和结直肠癌相关的宿主标志物.
- 持续的饮食调整对于高风险人群的持续健康益处至关重要.
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