结性脊柱炎与卵巢癌风险之间的因果关系
Xiao Ma1, Yongzheng Cui2, Congcong Shi3
1Department of Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, China.
Human immunology
|December 1, 2023
概括
根据孟德尔的随机化分析,结性脊柱炎 (AS) 与卵巢癌的风险增加有关. 瘤坏死因子受体超级家族21成员可能会调解这种关联,影响疾病的发展.
科学领域:
- 遗传学 是一个遗传学.
- 流行病学 流行病学
- 在瘤学瘤学.
背景情况:
- 脊髓炎 (AS) 是一种慢性炎症性疾病,主要影响脊椎.
- 在AS和患卵巢癌的风险之间的关系需要进一步调查.
- 了解潜在的因果关系对于风险评估和预防策略至关重要.
研究的目的:
- 为了调查结性脊髓炎 (AS) 和卵巢癌之间的潜在因果关系.
- 确定涉及AS和卵巢癌之间潜在联系的遗传因素和媒介.
主要方法:
- 利用来自欧洲祖先个体的公开可用的全基因组关联研究 (GWAS) 数据.
- 采用两样本的孟德尔随机化 (MR) 与逆方差加权 (IVW),加权中位数和MR-Egger回归.
- 确定了AS的单核酸多态 (SNP),并评估了它们对卵巢癌风险的因果关系,包括用于调解的网络MR分析.
主要成果:
- 确定了AS的23个重要的SNP,作为工具变量.
- 通过多种MR方法 (例如,IVW OR 1.147) 始终发现AS与卵巢癌风险增加之间的积极关联.
- 瘤坏死因子受体超级家族成员21被确定为调解者,解释了AS对卵巢癌风险的影响的10.2%.
结论:
- 门德尔的随机化分析提供了强有力的证据,表明AS和卵巢癌之间存在潜在的因果关系.
- 结性脊柱炎与卵巢癌的风险增加有关.
- 瘤坏死因子受体超级家族21号成员在AS和卵巢癌的发展中起着调解作用.
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