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Sara DelOlmo-Romero¹, Irene Medina-Martínez¹, Rocio Gil-Gutierrez¹

¹Institute of Biomedical Research (IBS), Granada, Spain; Nursing Department, Faculty of Health Sciences, University of Granada, Granada, Spain.

Medicina clinica

|December 1, 2023

概括

代谢综合征 (MetS) 影响了西班牙15%的系统性红斑狼 (SLE) 患者,与更高的疾病损伤和补充C3水平相关. 坚持地中海饮食可能有助于降低SLE中MetS的流行率.

科学领域:

类风湿病学类风湿病学
心脏病学心脏病学
内分泌学在内分泌学.

背景情况:

代谢综合征 (MetS) 是一组增加心血管风险,胰岛素抵抗和氧化损伤的疾病.
系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,通常与更高的MetS患病率有关.
了解SLE中的MetS对于管理这些患者心血管并发症至关重要.

研究的目的:

为了确定SLE患者的西班牙队列中MetS的流行率.
调查MetS与临床特征,心血管风险因素和SLE的饮食模式之间的关联.
评估MetS与SLE疾病活动,损伤和补充水平之间的关系.

主要方法:

一项涉及293名西班牙SLE患者的横截面研究.
基于国家胆固醇教育计划成人治疗小组III标准的MetS诊断.
评估SLE疾病活动 (SLEDAI-2K),损伤 (SDI) 和遵守地中海饮食 (MedDiet) 的情况.

主要成果:

在SLE患者队列中的15%中发现了MetS.
在MetS患者中,甘油三,高密度胆固醇,静脉血压和腰围均显著增加.
在患有MetS的SLE患者中观察到较高的SDI损伤指数和补充C3水平.

结论:

在这个SLE队列中,MetS的患病率低于之前报告的,可能与良好的MedDiet坚持有关.
在SLE中,MetS与与疾病相关的损伤 (SDI) 的增加有关,并补充C3水平.
在这个SLE群体中,MetS和药物使用之间没有发现显著的关联.

关键词:

疾病活动.损害指数损害指数地中海饮食地中海饮食疾病活动疾病活动系统性红斑狼 (Systemic Lupus erythematosus) 是一种严重的疾病.地中海饮食地中海饮食代谢综合征是代谢综合征.系统性红血性狼 (Systemic lupus erythematosusus) 是一种全身性狼.代谢综合症是代谢综合症.损害指数的使用情况.

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