在细菌感染期间,巨细胞代谢的进化拉战
Luís Almeida1, Ayesha Dhillon-LaBrooy1, Tim Sparwasser1
1Institute of Medical Microbiology and Hygiene, University Medical Center of Johannes Gutenberg University, Mainz 55131, Germany.
Trends in endocrinology and metabolism: TEM
|December 1, 2023
概括
巨细胞重新编程新陈代谢以对抗病原体,产生杀菌化合物. 然而,细菌在持续的免疫系统中利用这些宿主代谢变化.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 细胞的新陈代谢
背景情况:
- 巨细胞的功能对于病原体的检测和清除至关重要.
- 病原体的感知触发了巨细胞的两极分化和代谢重编程.
- 代谢变化支持效应器功能,并产生抗菌分子.
研究的目的:
- 在感染期间审查巨细胞代谢.
- 要突出宿主新陈代谢和细菌适应之间的相互作用.
- 了解宿主-病原体代谢"军备竞赛".
主要方法:
- 关于感染中巨细胞代谢的当前知识的文献综述.
- 专注于代谢重编程和二次代谢物生成.
- 分析细菌策略来操纵宿主新陈代谢.
主要成果:
- 巨细胞的代谢重编程对于获得病原体清除特性至关重要.
- 代谢途径产生具有直接微生物杀菌活性的二次代谢物.
- 细菌已经进化为操纵和利用巨细胞的代谢适应.
结论:
- 巨细胞代谢是宿主-病原体相互作用的关键战场.
- 了解这种代谢"军备竞赛"对于宿主防御至关重要.
- 准代谢途径可能提供新的治疗策略.
相关概念视频
Defense Against Bacterial Pathogens
1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Immune Surveillance by NK Cells and Phagocytes
1.4K
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
1.4K
Cells of the Innate Immune Response
1.7K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.7K


