固醇生物合成的共同起源表明,新原生态动物的养策略发生了转变
T Brunoir1, C Mulligan1, A Sistiaga2
1Department of Earth and Planetary Sciences, University of California, Davis, Davis, CA, USA.
Nature communications
|December 1, 2023
概括
岩石中的古老体暗示着早期的动物生活. 固醇甲基转移酶 (smt) 基因表明,早期的动物制造复杂的固醇,这种能力后来被许多人丢失了.
科学领域:
- 古遗传学是古遗传学的一部分.
- 分子进化分子进化
- 生物地质化学生物地质化学
背景情况:
- 沉积岩中的体是分子化石,表明在新新生态时代的真核生物进化.
- C27固醇与胆固醇 (红藻,动物) 有关,而C28和C29固醇与真菌和绿藻有关.
- 最近的发现表明,虫虫产生的C28和C29固醇,挑战了以前的假设.
研究的目的:
- 在动物中调查24碳固醇甲基转移酶 (smt) 基因的进化史.
- 为了确定早期的eumetazoans是否具备C28+固醇合成的能力.
- 为了将smt基因的多样化与斯特兰的地质记录联系起来.
主要方法:
- 在动物血统中对固醇甲基转移酶 (smt) 基因的基因分析.
- 分子时钟测定了SMT基因的进化分歧.
- 对 smt 基因演变与 C28 和 C29 固醇的平层形态外观进行比较.
主要成果:
- 证据表明,在整个动物进化过程中,smt基因的垂直遗传.
- 动物SMT基因的多样化与C28和C29菌根的新新生态上升相一致.
- 早期的甲动物很可能合成了C28+类固醇.
结论:
- 支持了早期动物产生C28+固醇的假设.
- 表明许多动物系在新新生态时期末期停止了C28+固醇生物合成.
- 这种放弃可能与真核生物猎物的可用性增加相吻合.
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