内在因素和CD1d1,但不是CD1d2表达水平控制不变的自然杀手T细胞子集分化
Ludivine Amable1, Luis Antonio Ferreira Martins1, Remi Pierre2
1Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), EMiLy, Paris, France.
Nature communications
|December 1, 2023
概括
不变的自然杀手T (NKT) 细胞分布在老鼠菌株之间因内在因素而异,而不仅仅是CD1d表达. T细胞受体信号和其他内在线索形成NKT细胞子集.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 不变的自然杀手T (NKT) 细胞是重要的免疫调节者.
- NKT细胞子集表现出不同的细胞因子配置和转录因子表达.
- 在C57BL/6 (B6) 和BALB/c小鼠菌株之间NKT细胞亚群分布存在显著差异.
研究的目的:
- 调查导致NKT细胞子集的菌株特异分布的因素.
- 确定CD1d分子在NKT细胞子集分化中的作用.
- 阐明NKT细胞编程中的内在细胞因子和外在信号之间的相互作用.
主要方法:
- 对C57BL/6和BALB/c小鼠NKT细胞种群的分析.
- 在骨髓衍生NKT细胞中NKT细胞子集分布的评估.
- 评估CD1d-连接体识别和T细胞抗原受体 (TCR) 信号强度的影响.
主要成果:
- 鼠标菌株之间的CD1d2表达差异不能完全解释NKT细胞子集的分布.
- NKT细胞子集的分布是NKT细胞的内在特征,独立于同源性CD1d-连接体的识别.
- CD1d表达水平和TCR信号强度影响NKT细胞的分布和功能.
结论:
- 菌株特异性NKT细胞子集分布主要由NKT细胞内的内在因素决定.
- CD1d介导的TCR信号和其他内在信号共同调节NKT细胞分化的途径.
- 了解这些内在机制是解读NKT细胞介导的株特异性免疫反应的关键.
相关概念视频
T Cell Activation and Clonal Selection
743
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
743
T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K
Cytotoxic T Cells-mediated Immune Response
923
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
923
Cells of the Innate Immune Response
1.7K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
1.7K


