在基于任务和休息状态的条件下,睡眠的对立的大脑特征
Mohamed Abdelhack1, Peter Zhukovsky2,3, Milos Milic1
1Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Nature communications
|December 1, 2023
概括
睡眠和抑郁症之间的关系是复杂的. 这项研究揭示了失眠和抑郁症的脑活动模式在任务和休息状态之间有所不同,挑战了以前的假设.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 睡眠医学 睡眠医学
背景情况:
- 睡眠和抑郁症表现出一种复杂的,双向的关系.
- 以前的研究通过检查有限的睡眠指标,抑郁症指标或神经成像技术,提供了一个不完整的观点.
- 了解这种关系的神经支对于有效治疗至关重要.
研究的目的:
- 为了研究大脑中睡眠,认知和抑郁的神经特征之间的相关性.
- 通过使用大规模数据集,分析跨任务和静止状态条件之间的这些关系.
- 挑战关于睡眠障碍和抑郁症神经功能表现的传统假设.
主要方法:
- 从任务和休息状态神经成像数据中分析大脑范围的神经特征.
- 利用来自英国生物银行和人类结合体项目的3万多个人的数据.
- 睡眠时间 (加速计),失眠,抑郁和认知措施的相关神经特征.
主要成果:
- 在任务条件下,失眠和抑郁症的神经特征与睡眠时间呈负相关性.
- 相反,这些特征与休息状态下睡眠时间正相关.
- 失眠和抑郁症与基于任务的低连接性和休息状态的超连接性有关,类似于休息状态的清醒模式.
结论:
- 不眠和抑郁的休息状态神经特征模仿了休息状态的清醒状态.
- 这些发现对睡眠障碍和抑郁症的神经功能相关的传统观点提出异议.
- 观察到的任务与静止状态连接的差异可能解释了先前研究中的不一致性.
更多相关视频
10:43Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
Published on: July 1, 2014
15.1K
06:40Microstate and Omega Complexity Analyses of the Resting-state Electroencephalography
Published on: June 15, 2018
10.2K
相关概念视频
Sleep-Wake Cycles
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
Understanding Sleep
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
Insufficient Sleep and Sleep Deprivation
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
Stages of Sleep
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
REM Sleep Behavior Disorder
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
Substance Use Disorders Affecting Sleep
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
Understanding the concepts of physical dependence,...
