血清代谢基因组和肝脏转录基因组揭示了吸入阿克罗莱因引起的性别特异的恒常功能障碍
Devin I Alewel1, Katherine M Rentschler1, Thomas W Jackson1
1Oak Ridge Institute for Science and Education Research Participation Program, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.
Scientific reports
|December 1, 2023
概括
暴露于阿克罗莱因会在老鼠中引起性别特定的代谢变化,在雄性和雌性之间影响脂质和氨基酸不同. 这突显了吸入阿克罗莱因与慢性代谢疾病之间的潜在联系.
科学领域:
- 环境毒理学环境毒理学
- 代谢学 代谢学 代谢学
- 系统生物学 系统生物学
背景情况:
- 阿克罗莱因是一种呼吸系统刺激物,已知会引起神经内分泌应激.
- 阿克罗莱因暴露的周围代谢效应尚未得到广泛研究.
- 越来越多地认识到毒理反应的性别差异.
研究的目的:
- 为了研究性特异性系统代谢和转录基因对急性亚克罗莱因吸入的反应.
- 在雄性和雌性大鼠中表征阿克罗莱因暴露的周围代谢效应.
- 为了确定潜在的生物标志物和受阿克罗莱因影响的途径.
主要方法:
- 雄性和雌性WKY大鼠被暴露在空气或阿克罗莱因 (3.16 ppm) 中4小时.
- 血清代谢量和肝脏转录量 (仅男性) 在暴露后进行.
- 统计分析确定了差异丰富的代谢物和基因表达模式.
主要成果:
- 阿克罗莱因暴露导致男性超过174个代谢物的性别特异性变化,女性超过50个代谢物.
- 雌性对亚克罗莱因的代谢排毒更大,由更高的生物标志物水平表明.
- 男人表现出循环中的自由脂肪酸,脂质,分支链氨基酸和皮质的增加,肝脏转录组显示了脂质和蛋白质代谢途径的改变.
结论:
- 急性阿克罗莱因吸入会诱导明显的性别特异性血清代谢和肝脏转录基因变化.
- 男性的这些代谢障碍可能与神经内分泌应激和肠道微生物组变化有关.
- 这些发现表明,暴露在阿克罗莱因和慢性代谢疾病的发展之间存在潜在的联系.
相关概念视频
Genetic Lingo
Overview
Pedigree Analysis
Overview
X-linked Traits
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
Sex-linked Disorders
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
X-linked Traits
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.
Human Genetics
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...


