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处理方法对Posaconazole无形固体分散物的物理化学性质的影响

Ru He1, Matthew S Lamm1, Andrew Brunskill1

  • 1Analytical Research & Development, Merck & Co., Inc., Rahway, NJ, 07065, USA.

Pharmaceutical research
|December 1, 2023
PubMed
概括

与热挤出相比,喷雾干燥产生的Posaconazole无形固体分散 (ASD) 的化学稳定性较低. 然而,所有ASD都表现出类似的溶解和超和行为,无论处理方法如何.

关键词:
无形固体分散的无形固体分散结晶化 结晶化的过程.这是一种配方配方.喷雾干燥 喷雾干燥过度和是一种超和.

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