菌突变超级菌会影响Candida albicans的毒性
Maíra Terra Garcia1, Jéssica Diane Dos Santos2, Paulo Henrique Fonseca do Carmo2
1Department of Biosciences and Oral Diagnosis, São Paulo State University (UNESP), Institute of Science and Technology, Av. Engenheiro Francisco José Longo, 777, São José dos Campos, SP, 12245-000, Brazil. maa.terra@hotmail.com.
概括
来自Streptococcus mutans (SM-S) 的代谢物减少了Candida albicans的毒性. 预处理的C. albicans表现出抑制的生长,粘附和生物膜形成,导致Galleria mellonella幼虫的感染减少.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 抗菌研究 抗菌研究
背景情况:
- 香菌 (Candida albicans) 是一种主要的人类病原体,导致香病.
- 有限的抗真菌剂需要新的治疗策略.
- Streptococcus mutans 的代谢物显示出潜在的抗真菌活性.
研究的目的:
- 为了研究Streptococcus mutans supernatant (SM-S) 对Candida albicans毒性因子的影响.
- 评估经过SM-S预处理后幸存下来的C. albicans的修饰性毒性和传染性.
- 评估SM-S在开发新型候群病治疗中的潜力.
主要方法:
- 已经准备好了Streptococcus mutans超级菌 (SM-S) 的研究.
- 在24小时内,Candida albicans细胞用SM-S进行了预处理.
- 在体外测试中评估了细胞生长,粘附,生物膜形成和蛋白质分解活性.
- 在体内测试中使用Galleria mellonella幼虫来评估感染性和血细胞反应.
主要成果:
- SM-S 预处理显著抑制了 C. albicans 菌株的生长,改变了粘附性,并损害了生物膜的形成.
- C. albicans的蛋白质分解活性不受SM-S的影响.
- 在体内,预处理的C. albicans在G. mellonella中显示感染能力降低.
- 在被预先处理的C. albicans感染的G. mellonella中观察到更高的循环血细胞数量.
结论:
- 突变性白杆菌 (Streptococcus mutans supernatant,简称SM-S) 有效地抑制了白杆菌 (Candida albicans) 的关键毒性因素.
- 在G. mellonella感染模型中,SM-S预处理降低了C. albicans的病原性.
- 这些发现表明,SM-S是新型 кандидоз治疗策略的有希望的候选者.
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