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Updated: Jul 9, 2025

gDNA Enrichment by a Transposase-based Technology for NGS Analysis of the Whole Sequence of BRCA1, BRCA2, and 9 Genes Involved in DNA Damage Repair
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在泛癌队列中的BRCA1/2逆转突变

Kohei Nakamura1,2, Hideyuki Hayashi1, Ryutaro Kawano1

  • 1Genomics Unit, Keio Cancer Center, Keio University School of Medicine, Tokyo, Japan.

Cancer science
|December 2, 2023
PubMed
概括

阴性BRCA1/2逆转突变可以恢复蛋白质功能,导致癌症患者的耐药性. 这项研究在12名日本患者中发现了32种癌症类型的耐药性突变,突出显示了它们即使在非BRCA相关癌症中也会发生.

关键词:
这就是BRCA1/2的原因.这是一种PARP抑制剂.同类重组缺陷的同类重组缺陷.基于的化学疗法.逆转突变是一种逆转突变.

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