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同时分裂肝脏/脏移植:国家和单一中心经验报告

Radhika Rastogi¹, Paola A Vargas¹, Jose Oberholzer¹

¹Department of Surgery, Division of Transplantation, University of Virginia Health System, Charlottesville, Virginia, USA.

Clinical transplantation

|December 2, 2023

概括

同时分裂肝脏和脏移植 (SSLK) 是对末期肝脏和脏疾病患者的一种安全有效的程序. 这种方法优化了器官供应,并提供了强大的生存率,使其成为移植中心的可行选择.

科学领域:

移植医学是一种移植医学.
器官移植器官移植器官移植
腎病學和肝病學.

背景情况:

末期肝病 (ESLD) 和末期病 (ESRD) 需要移植,但器官稀缺是一个主要的挑战.
分裂肝移植越来越多地用于最大限度地提高ESLD患者的器官可用性.
同时分割肝脏和脏移植 (SSLK) 为患有并发性ESLD和ESRD的患者提供了潜在的解决方案.

研究的目的:

调查同步分裂肝脏和脏移植 (SSLK) 的国家趋势和结果.
评估SSLK的可行性和安全性,作为肝脏和脏衰竭组合患者的治疗选择.
评估 SSLK 程序后的移植和患者存活率.

主要方法:

美国器官共享网络 (UNOS) 标准移植分析和研究 (STAR) 文件的回顾性审查.
分析涵盖了从2011年1月到2022年4月接受初始SSLK的成年患者.
描述性分析包括手术前的特征,手术后的结果,以及精算上的移植和患者存活率.

主要成果:

SSLK仍然是一种不常见的手术,在2011年至2021年期间,全国仅发现了76例病例.
观察到强的生存率:1年94%,3年92%,5年90%的患者总体.
移植存活率也很高:在1年内90% (肝脏) 和93% (脏),在单个中心的经验中没有报告过移植并发症.

结论:

SSLK是一种安全可行的移植策略,有效利用可用器官.
该程序允许接受者接受高质量的肝脏和脏移植,改善并发症患者的治疗结果.
移植中心应该更频繁地考虑SSLK,以优化器官供应,并满足ESLD和ESRD组合患者的需求.

关键词:

国家UNOS注册表数据数据.结果就是结果.同时进行肝/移植.同时分裂肝脏/脏移植切割肝移植移植切割肝移植

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