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Updated: Jul 9, 2025

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基于生理学的sparsentan的药理动力学模型,以评估潜在的药物相互作用

Nikunjkumar K Patel1, Kuan-Fu Chen1, Shang-Chiung Chen2

  • 1Simcyp Division, Certara UK Limited, Sheffield, UK.

CPT: pharmacometrics & systems pharmacology
|December 2, 2023
PubMed
概括

斯帕森坦是一种双重内甲素/ ангиотензинII受体对抗剂,当与强大的CYP3A4抑制剂一起服用时,可能会显著增加暴露. 抑制P-葡萄糖蛋白对斯帕森坦的药理动力学影响微不足道.

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