在现实世界中药用和对萨库比特里尔/瓦尔萨坦的坚持:HFrEF中的REAL.IT研究
Massimo Iacoviello1, Gabriele Di Gesaro2, Filippo Maria Sarullo3
1Surgical and Medical Sciences Department, University of Foggia, Foggia, Italy.
ESC heart failure
|December 2, 2023
概括
在意大利实践中,萨库比特里尔/瓦尔沙坦的使用表明,在心力衰竭患者中,其剂量迅速提升至目标剂量,并具有很高的坚持性. 这种有效的管理符合欧洲心脏病学会关于减少弹射率的指导方针.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 现实世界的证据研究研究.
背景情况:
- 欧洲心脏病学会 (ESC) 的指导方针为心力衰竭 (HF) 治疗提供了明确的指示.
- 关于药物的有效性,坚持和持续性的真实数据对于优化HF管理至关重要.
- 萨库比特里尔/瓦尔沙坦是减少射出分数 (HFrEF) 的HF的关键治疗方法.
研究的目的:
- 调查意大利HFrEF患者中萨库比特里尔/瓦尔沙坦的实际使用,有效性,坚持性和持续性.
- 评估目标剂量的实现情况,并确定剂量修改或中止的原因.
主要方法:
- 观察性,回顾性,非干预性队列研究,使用来自意大利9家医院高频中心的电子病历.
- 分析了948名处方sacubitril/valsartan的患者,并对924名患者进行了12个月的详细随访.
- 评估药物使用,剂量定位,坚持,持续性和与HF相关的住院治疗.
主要成果:
- 45.2%的患者在平均6.9周内达到萨库比特里尔/瓦尔沙坦 (97/103毫克) 的目标剂量;主要障碍是血压问题和恶化的病.
- 大约50%的患者经历了剂量变化,70.2%的患者在12个月内持续接受治疗. 在53%的患者中观察到完全遵守.
- 低血压是停止治疗的主要原因 (14.2%). 在非持久性患者中,数字上更高的HF住院病例被注意到.
结论:
- 来自意大利的现实数据表明,在HFrEF患者中,萨库比特里尔/瓦尔萨坦的有效和快速定位.
- 高度的治疗坚持和持续性支持与ESC指南相一致的良好治疗管理.
- 该研究强调了在常规临床实践中优化萨库比特里尔/瓦尔萨坦治疗的可行性.
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