根据母亲的铁储量调整的产前铁补充剂减少了4岁儿童的行为问题
Lucía Iglesias-Vázquez1,2, Josefa Canals1,3, Carmen Hernández-Martínez1,3
1Department of Basic Medical Sciences, Nutrition and Mental Health (NUTRISAM) Research Group, Universitat Rovira I Virgili, Reus, Spain.
Maternal & child nutrition
|December 2, 2023
概括
根据母亲的铁含量调整产前铁剂量可以改善儿童的行为. 个性化的铁补充剂通过解决个体母亲的铁储存来减少幼儿的行为问题.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 营养科学 营养科学
背景情况:
- 产前补充铁对母亲和胎儿的健康至关重要.
- 虽然对儿童健康和认知的好处已知,但对行为发展的影响需要进一步调查.
- 在怀孕早期,母亲的铁状况会影响胎儿的发育和长期儿童的结果.
研究的目的:
- 评估适合孕前铁补充剂,调整为母亲的铁储量,对儿童行为问题的影响.
- 研究不同铁剂量,母体血红蛋白 (Hb) 和血清费里丁 (SF) 水平以及4岁儿童行为之间的关系.
- 为了确定个性化的铁补充策略是否可以减轻幼儿时代的行为问题.
主要方法:
- 这是一项随机对照试验,涉及230名西班牙塔拉戈纳的非贫血孕妇,随访时间为4年.
- 在妊娠第12周之前,女性根据Hb水平和SF度接受了不同的铁剂量 (20,40或80毫克/天).
- 用家长和教师报告 (儿童行为检查清单,执行功能行为评级清单-学龄前版本,教师报告表) 评估儿童行为.
主要成果:
- 高剂量的铁 (80毫克/天) 改善了母亲铁储量低的孩子的行为,但在那些正常高储量的孩子中恶化了行为 (除了抑郁和注意力/多动问题).
- 低剂量铁 (20毫克/天) 仅在母亲SF水平高 (>65微克/升) 的儿童中改善了行为.
- 当母体基线SF低 (<15μg/L) 时,高剂量的铁改善了执行功能.
结论:
- 将产前铁补充剂调整为母亲的Hb和铁储量,有效地减少了4岁儿童的行为问题.
- 个性化的铁剂量策略可以通过考虑到个体母亲的营养状况来优化发育结果.
- 这种方法强调了怀孕期间个性化营养干预对儿童长期福祉的重要性.
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