治疗B细胞急性淋巴细胞白血病的奇默抗原受体T细胞治疗后儿童的感染
Yonatan Diamond1, Maddie Gilsenan2, Stacie Shiqi Wang2,3
1Kids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales, Australia.
概括
接受CD19导向的仿真抗原受体T细胞 (CAR-T) 治疗B细胞急性淋巴细胞白血病 (B-ALL) 的儿科患者的感染率较低. 目前的抗微生物预防策略在这个脆弱人群中似乎是有效的.
科学领域:
- 儿科瘤学 儿科瘤学
- 传染性疾病 传染性疾病
- 免疫治疗是一种免疫疗法.
背景情况:
- CD19导向的CAR-T疗法是儿科复发/耐药B细胞ALL的突破.
- 有限的儿科数据存在感染风险和预防治疗后CAR-T治疗的充分性.
研究的目的:
- 在CAR-T治疗100天内,描述小儿B-ALL患者的抗菌预防和感染类型.
- 评估当前预防指南在这个群体中的有效性.
主要方法:
- 对抗微生物预防和传染性并发症的回顾性审查.
- 对儿童患者 (≤18岁) 的CAR-T输注后前100天数据的分析.
主要成果:
- 在27名患者中,有6人 (22%) 在CAR-T后100天内出现感染.
- 细菌性血流感染是最常见的;发生了一例可能的肺阿斯伯吉洛症病例.
- 没有报告感染相关的死亡,这表明预防的有效性.
结论:
- 在CAR-T治疗后的儿科B-ALL患者的感染谱的特征.
- 观察到的传染性并发症率低于之前报告的水平.
- 目前的预防建议在这个儿科队列中表现出有效性.
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