老年人的多发性疾病,认知表型和阿尔茨海默病等离子体生物标志物:基于人口的研究
Yifei Ren1, Yuanjing Li2, Na Tian1,3,4,5
1Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P. R. China.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|December 2, 2023
概括
慢性疾病的数量及其集群与老年人的痴呆症,轻度认知障碍和阿尔茨海默病生物标志物有关. 特定的多病症模式与痴呆症亚型和生物标志物有明显的关联.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 多病症,多种慢性疾病的存在,在老年人中很常见.
- 了解多病症对认知衰退和阿尔茨海默病的影响对于公共卫生至关重要.
- 多病症的特定模式可能会影响认知障碍的风险和表现.
研究的目的:
- 调查多发病和轻度认知障碍 (MCI),痴呆症和阿尔茨海默病 (AD) 相关的血生物标志物的负担和集群之间的关联.
- 识别不同的多病态模式及其对老年人认知健康的影响.
主要方法:
- 一项针对5432名老年人 (≥60岁) 的基于人口的研究.
- 用于定义23种慢性疾病的5个多病症集群的等级分类.
- 使用国际标准诊断的痴呆症和MCI;在子样本中测量了血生物标志物 (氨基酸β,,NfL).
主要成果:
- 慢性疾病的数量增加与痴呆,AD,血管痴呆 (VaD) 和非遗忘性MCI的更高几率相关.
- 特定的多病症集群 (代谢,退行性眼病) 显示了与VaD,非记忆力MCI和AD的差异关联.
- 较高的慢性疾病负担与血粉样蛋白β和NFL水平的升高有关.
结论:
- 多种疾病负担和特定群体与老年人痴呆症亚型,MCI和AD相关的血生物标志物有差异性相关.
- 这些发现突显了慢性疾病和认知健康之间的复杂相互作用,为有针对性的干预提供了信息.
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