脉冲重复频率对气泡云特征和单循环基因组缩中的切除的影响
Alex Simon1, Connor Edsall1, Adam Maxwell2
1Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA, United States of America.
Physics in medicine and biology
|December 2, 2023
概括
脉冲重复频率 (PRF) 显著影响基因囊气泡云特征和洞穴值. 与冲击散射方法不同,单循环组织缩中较高的PRFs不会降低切除效率.
科学领域:
- 超声波技术的超声波技术
- 声学腔化是一种声学腔化.
- 生物医学工程 生物医学工程
背景情况:
- 组织透是一种新兴的超声波除技术,利用洞腔.
- 了解脉冲参数的影响对于优化组织缩至关重要.
- 单循环脉冲是一种特定的组织缩操作模式.
研究的目的:
- 为了研究脉冲重复频率 (PRF) 对泡云特征在组织缩中的影响.
- 评估PRF如何影响基因组的消灭能力.
- 为了将这些发现与之前关于冲击散射组织缩症的研究进行比较.
主要方法:
- 一个500kHz的基因组透系统被用来产生从0.1到1000Hz的PRF的气泡云.
- 高速光学成像可视化了1%阿加罗斯组织幽灵中的泡云.
- 通过使用红细胞 (RBC) 幻象来评估消耗能力.
主要成果:
- 洞穴云值随着PRF的增加而下降 (从0.1Hz的26.7MPa到1000Hz的15.0MPa).
- 气泡云密度在较高的PRF下降,但云仍然填满了焦点体积.
- 损伤对焦区域的粘附性在较高的PRF下降,但整体消去效率仍然保持一致.
结论:
- 在单循环组织缩中,PRF极大地影响了气泡云动态和腔化值.
- 与冲击散射组织缩相反,更高的PRFs在这种单循环方法中不会降低切除效率.
- 这些发现对于指导未来的组织缩脉冲策略至关重要.
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