激发性和炎症介质由两极化的M1和M2巨细胞产生,这些巨细胞被D-二聚体和SARS-CoV-2尖峰免疫复合体激活

Yun-Jong Park1, David Acosta2, Mohammad Rubel Hoq2

  • 1Division of Viral Products, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Silver Spring, MD, USA; Division of Hemostasis, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Silver Spring, MD, USA.

Cytokine
|December 2, 2023
PubMed
概括

免疫复合体 (IC) 与SARS-CoV-2尖端蛋白和D-二次体 (DD) 触发肺巨细胞的炎症反应. 这种相互作用,特别是与M1巨细胞的相互作用,表明一种机制导致严重的COVID-19炎症.

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