在患有子宫癌的患者中,雌激素替代疗法和非激素药物使用
Yukio Suzuki1, Ling Chen1, Jennifer S Ferris2
1Columbia University College of Physicians and Surgeons, New York, NY, United States.
Gynecologic oncology
|December 2, 2023
概括
在术后的子宫癌患者中,雌激素替代疗法 (ERT) 的使用量有所下降,非激素药物变得越来越普遍. 这种转变会影响这些患者的生活质量管理.
科学领域:
- 在瘤学瘤学.
- 妇科 妇科 妇科 妇科
- 药理学 药理学是指药理学的学科.
背景情况:
- 子宫内膜癌的预后是有利的,使治疗副作用的管理对患者的生活质量至关重要.
- 手术后的雌激素缺乏对女性的健康和福祉产生重大影响.
研究的目的:
- 分析雌激素替代疗法 (ERT) 和子宫切除术后子宫癌患者的非激素药物使用趋势.
- 为了比较子宫癌患者和患有良性疾病的对照人群之间的药物使用模式.
主要方法:
- 利用MarketScan数据库 (2008-2020年) 针对18-75岁的接受子宫切除术的患者.
- 员工倾向性得分平衡和差异差异 (DID) 分析,以比较手术前和手术后的药物使用.
- 使用Cochran-Armitage趋势测试评估ERT使用趋势.
主要成果:
- 与对照组相比,子宫癌患者的术后ERT使用量显著下降 (DID:在18-49岁时为-37.1%,在50-75岁时为-10.4%).
- 在子宫切除术后的子宫癌患者中,非激素药物的使用增加 (DID:11.2%为18-49岁,3.4%为50-75岁).
- 随着时间的推移,在子宫癌患者的两个年龄组中观察到新的术后ERT使用的下降趋势.
结论:
- 雌激素替代疗法 (ERT) 的使用在子宫癌患者中不常见且正在下降.
- 非荷尔蒙药物越来越多地被用于管理子宫癌幸存者的更年期症状.
- 这些药物趋势是优化子宫内膜癌幸存者的生活质量的重要考虑因素.
相关概念视频
01:24Disorders of the Female Reproductive System
368
The female reproductive system can be affected by several disorders, including Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), endometriosis, and various forms of cancer. PMS and PMDD are cyclical conditions that cause physical and emotional distress, with symptoms that include edema, mood swings, and food cravings. PMDD is a more severe form of PMS characterized by increased symptom severity that peaks during the luteal phase and tends to improve or resolve shortly after...
368
01:28Menopause
171
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
171
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
01:22Birth Control Methods
272
Vasectomy is a surgical form of male sterilization that involves severing and sealing the vasa deferentia, preventing sperm from mixing with semen during ejaculation. Because a vasectomy does not impact the testes' ability to produce testosterone, hormone levels, libido, and sexual function generally remain unchanged. While vasectomy is highly effective in preventing pregnancy, with a success rate near 99.85%, rare cases of recanalization (spontaneous reconnection) can occur. Although...
272