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新诊断结核病患者的血液学参数:系统性审查和元分析
Maryam Farhadian1, Sobhan Veisi2, Negin Farhadian3
1Department of Biostatistics, School of Public Health, Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran.
Tuberculosis (Edinburgh, Scotland)
|December 2, 2023
概括
结核病 (TB) 显著影响造血系统,经常导致贫血和患者的ESR升高. 了解这些血液学变化有助于早期结核病诊断和管理.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 结核病 (TB) 仍然是全球主要的健康威胁,对全球死亡率作出重大贡献.
- 结核病对造血系统的影响尚未得到充分证实,因此需要进一步研究血液学概况.
研究的目的:
- 系统地审查和对新诊断的结核病患者的血液学参数进行元分析.
- 为了改善临床实践,识别与结核病相关的常见血液异常.
主要方法:
- 在PubMed进行了全面的文献搜索,截至2023年4月.
- 15项涉及3354名患者的研究被纳入了系统性审查和元分析.
- 进行了一个样本和两个样本的元分析,以汇集血液学参数的数据.
主要成果:
- 在结核病患者中,聚合分析显示了低血红蛋白 (Hgb) 水平 (11.679 g/dl) 和升高的红细胞沉积率 (ESR) (63.569 mm/h).
- 在结核病患者中,贫血的患病率为61.6%,白细胞瘤45.9%,血栓细胞瘤31.9%,淋巴缺血23.1%.
- 与健康对照组相比,结核病患者的红细胞 (RBC) 和Hgb水平显著较低 (p <0.05).
结论:
- 新确诊的结核病患者经常表现出血液学异常,包括贫血,ESR升高,白细胞症和淋巴衰竭.
- 了解这些常见的血液检测结果可以帮助医生在结核病的早期诊断和有效管理.
- 对结核病的血液学表现的进一步研究可以改善患者的治疗结果.
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